We have recently synthesized a series of phosphorylated flavonoids and identified some of
them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity
for CEase over acetylcholinesterase (AChE). In the present paper, we investigated the
inhibitory activities of these compounds against porcine liver carboxylesterase (CE) since
carboxylesterases (CEs) are another family of serine esterases responsible for the
metabolism and detoxification of many ester-containing xenobiotics and clinical esterified …